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Schedule

创新思维与交叉研究

Innovation Through Intersisciplinery Research

主讲：徐峰

Lecture：Feng Xu

摘要：开展学科交叉研究是科学发展的必然规律，是实现科技创新最有效的科研方式之一。进入二十一世纪以来，力学学科的发展日新月异，不断向交叉领域、边缘领域扩展，向高温、高速、高压等极端条件迈进，研究的复杂性和难度不断增大，越来越需要重视学科交叉和发展。这些都对创新型、复合型力学人才的培养提出了新的要求。同时，学科交叉也由学科内交叉（如材料学、力学、声学、传热学、物理、化学、生命科学等）发展为大学科间的交叉融合（如哲学、理学、工程学、医学等）。这一背景下，交叉融合力学、材料科学、生命科学、医学等学科，从多个层次、多个角度开展 “仿生工程与生物力学”的基础和应用研究，揭示生命体中的结构和功能的相互关系以及普适性规律，才能取得一批高质量的原创性交叉学科研究成果。报告中，我将从个人经历以及我们中心（仿生工程与生物力学中心）的科研给大家展示如何从交叉研究中获得灵感并产生创新思想。

Abstract：It has been realized that even for a simple biological and medical questions, it is challenging to solve with knowledge from any single disciplinery.  Actually, most innovations have been achieved through collobaration from people with different backgrounds.  In this talk, I will start from my experience and then move to the ungoing research in our center (Bioinspired Engineering and Biomechanics Center) to show how to achieve innovation through intersisciplinery research.  BEBC aims at advancing human health through academic excellence in education and research that integrates engineering, science biology and medicine.  We educate outstanding minds, cultivate leaders, create knowledge, and generate cost-effective preventative, diagnostic, and therapeutic innovations.  Conversely, it brings clinical insight from the patient’s bedside to the laboratory bench.  In this way, our students are trained to carry their engineering and scientific expertise from the laboratory bench to the patient’s bedside and to bring clinical insights from the patient’s bedside to the laboratory bench; to have deep understanding of engineering, physical sciences, and the biological sciences, complemented with hands-on experience in the clinic or in industry; and they become conversant with the underlying quantitative and molecular aspects of medicine and biomedical science.

组织工程与再生医学

Tissue Engineering and Regenerative Medicine

主讲：张晓慧

Lecturer: Xiaohui Zhang

摘要：组织工程/再生医学是一个新兴的多学科领域，涉及生物学、医学和工程学，旨在通过恢复、维持或增强组织和器官功能来改善健康和生活质量。它可以通过组织移植而实现治疗应用或将组织用于药物筛选而实现诊断应用。组织工程特别在细胞来源、生物材料、生物分子、生物制造方法等方面取得了重大进展。报告将举一些代表性的实例来展示该领域取得的重要成果。

Abstract: The Internet of Things (IoT for short) is an important part of a new generation of information technology. It means installing sensors for everything, and connecting them to the Internet through specific protocols for information exchange and communications, in order to achieve intelligent recognition, location, tracking, monitoring and management in the whole process of information collection, transmission, storage and processing. As an emerging field, IoT has drawn great attention of academia, IT, and industry, so it is called the third wave of world information industry after the computer and the Internet. IoT is a convergence of multiple technologies, including ubiquitous wireless communication, real-time analytics, machine learning, commodity sensors, and so on. Firstly, the development and convergence of Internet technology and mobile communication technology has been reviewed. The target of these technologies has shifted from the connection of anyone at anytime and anyplace to the connection of anything. So comes the Internet of Things. Secondly, IoT architecture has been explained. The background, current situation and trends are discussed in detail of such techniques as 2D barcode, RFID, big data, cloud computing and so on. Thirdly, applications of IoT are introduced in the following fields, such as smart city, smart home, smart transportation, smart dust, smart environmental monitoring, etc. Last, the future vision of IoT has been discussed.

聚羟基脂肪酸酯微球及其生物医药应用

Polyhydroxyalkanoate Nanoparticles and the applications in Biotechnology and Biomedicine

主讲：卢晓云

Lecturer：Xiaoyun Lu

主要内容：PHA 纳米微球是很多微生物在营养失衡的情况下，在体内合成的一种可生物降解的细胞内聚酯，主要作为微生物的碳源及能量储备。天然PHA微球的内部是由疏水的聚酯链构成的疏水核心，其外层是由磷脂界膜及膜上嵌入或附着的包括PHA合酶PhaC和PHA颗粒相关蛋白PhaP等蛋白构成的边界层。PhaC通过共价键连接在PHA微球表面，而PhaP通过疏水相互作用吸附在PHA微球表面。将外源性功能蛋白与PhaC或PhaP进行融合表达，在重组微生物体内就能直接合成表面带有功能蛋白的纳米微球复合体。由于该纳米微球在微生物细胞内是以独立的包涵体形式存在，因此通过细胞破碎及离心等方法就能简便、有效地使其从细胞中分离并得以纯化。鉴于PHA微球这种表面易被修饰改造的特性，越来越多的功能蛋白通过与PHA 微球表面蛋白（PhaC 或PhaP）的融合表达，呈递在了PHA微球表面，使其成为一种廉价、高效的蛋白固定化及呈递的新技术。本文在介绍了PHA微球的结构特性及生物合成的基础上，着重综述了目前关于功能化PHA微球在蛋白纯化、固定化酶、生物分离、靶向递药、疾病诊断、成像技术及新型疫苗开发方面的研究现状及其未来在生物医药等领域的广泛应用前景。

Abstract：Polyhydroxyalkanoates (PHAs) are a family of biodegredable polyesters which are synthesized by a wide range of bacteria as the energy- and carbon-storage materials. PHA nanoparticles are insoluble spherical inclusions in the cytoplasm, which consists primarily of an amorphous, hydrophobic polyester core, surrounded by an outsidephospholipid monolayer enbeded with viarious associated proteins such as PHA synthase (PhaC) and PHA granule associate protein Phasin (PhaP). PhaC is covalently linking with PHA polymer chain, whereas PhaP attaches to the PHA nanoparticles through hydrophobic interactions. Therefore, through fusing the target proteins with either PhaC or PhaP, viarious functionalized PHA nanoparticles with target proteins immobilized on the granule surface could be synthesized by the genetically engineered bacteria. These nanoparticles are water-insoluble inclusions that can be easily and efficiently purified simply through cell disruption and centrifugation. In recent years, a number of bioactive peptides or proteins have been reported to be immobilized on the surface of PHA granules in vivo by recombinant bacteria such as gram-negative Escherichia coli based on this strategy. It provides a powerful but convenient and low-cost technique to achieve specific functionalized PHA nanoparticles which could be applied in many potential areas in the biological and biomedical fields. In this review, the recent investigations on viarious functionalized PHA nanoparticles were summarized after a simple introduction of the structure and biogenesis of natural PHA granules, and the current applications of some functional PHA particles in specific areas such as protein purification, enzyme immobilization, bioseperations, targeted drug delivery, diagnostics, imaging and being vaccines were also introduced.

一带一路与中国文化

The Chinese Culture and One Belt One Road

主讲：万 翔

Lecture：Xiang Wan 

摘要：本次课程将介绍一带一路倡议及其相关教育、就业政策，以及中国和有关国家友好交往的历史。本次课程的主题是：中国文化从来都是开放的文化，丝绸之路是中国联系世界的纽带，中国的一带一路倡议将为世界人民造福。教师除了讲授课程内容之外，还鼓励学生介绍自己国家的历史文化，以及自己留学中国以后的就业和深造计划。

Abstract: This class will provide an introduction to the One Belt One Road Initiative and its relevant educational and employment policies, along with the history of China’s friendship with worldwide countries. The theme of this class is that the Chinese culture is open to the globe, that the Silk Road connects China with the rest of the world, and that the One Belt One Road Initiative will make benefit the people universally. In addition to lecturing, the teacher will also encourage the students to speak about the cultures of their own countries, as well as their plans for employment and further studies.

HSK提升——中国的美食
Enhance Your Chinese Language Ability through Knowing Culinary Delights in China

摘要：饮食是中国文化的一大亮点。中国美食遍布全世界，深受各国人民的喜爱。中国人自古以来就重视饮食，人们常说“民以食为天”。特殊的节庆人们会食用有节日特色的美食。中国饮食的名称，五花八门，每个著名的名称背后都有一段美妙的故事。在讲座中将带你了解中国的八大菜系、著名的菜式及他们的故事。通过了解中国的饮食文化，将有助于你了解中国人的风俗习惯、审美趣味和生活态度等丰富的文化内涵。

Abstract: Chinese cuisine is a brilliant facet of Chinese culture which originated from different regions of China and has become widespread all over the world. The Chinese saying goes “Food is the first necessity of the people.” Chinese people have special food in some festivals. Color, aroma and taste are the three essential factors which are considered when judging Chinese dishes. The Eight Well-known Schools of Chinese Cuisine will be introduced in the lecture. Stories about certain dishes will also be told in the lecture. Knowing Chinese cuisine will help you understand Chinese customs, aesthetic tastes and people’s attitudes toward life.